Do chemicals in the environment affect fertility?

The amount of chemicals absorbed is thought to be so minute that they would be difficult to discern through testing. However, through a process known as bioaccumulation, chemicals can become concentrated in individuals over a number of years, stored mostly in fat tissue. Though these chemicals may not be directly harmful to these individuals, if they are passed on — for example, through gestation in the womb or through the food chain — they might have consequences for human health.

“One of the concerns of bioaccumulation is that when the fat is broken down and passed on — for example during the breast feeding process — the offspring are exposed to a concentration of chemicals that the mother has built up over the years,” said Dr Sinclair.

Colleagues in Aberdeen have provided precise measurements of specific chemicals in the environment and in animal tissues. These often take the form of chemicals which mimic hormones.

“These chemicals come from a variety of sources including plastics, pesticides and industrial waste and many of these persist in the environment for a long time — albeit at very low levels,” said Dr Lea. “The problem is even low levels can still have an effect.”

The three-year study will look at how chemicals are passed on from mother to foetus, and how this impacts on the foetus. It is thought that, although this generation of animals may have no problems getting pregnant, the next and future generations could have fertility problems stemming from exposure to environmental chemicals in the womb.

Dr Lea said: “Though male fertility has been the subject of studies in recent years, this will be the first time that female fertility has been examined. Currently, less is known about the effects of hormone-like chemicals on the developing female foetus, so the consequences for reproductive development in females may be greater than in males.”

“We're not talking about obvious congenital defects here, but tiny changes caused by exposure to chemicals that have an impact on reproductive function — changes over generations rather than immediate effect,” added Dr Sinclair.

The inaugural meeting of the REEF consortium will take place in Copenhagen on Thursday 22 and Friday 23 May to formally launch the project.

Source:http://communications.nottingham.ac.uk/News/